Publications

Asterisk(*) - indicates co-first author

Underline - indicates student author

Peer-Reviewed Publications

  1. Zajac, C., Scott, N. E., Kline, S., Erayil, S. E., Selmecki, A. (2025). Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates. npj antimicrobials and resistance, 3(1), 31. PMID: 40247099 PMCID: PMC12006411 doi: 10.1038/s44259-025-00102-6
  2. Oggenfuss, U., Todd, R. T., Soisangwan, N., Kemp, B., Guyer, A., Beach, A., Selmecki, A. (2025). Candida albicans isolates contain frequent heterozygous structural variants and transposable elements within genes and centromeres. Genome research, 35(4), 824-838. PMID: 39438112 PMCID: PMC12047244 doi: 10.1101/gr.279301.124
  3. Scott, N. E., Wash, E., Zajac, C., Erayil, S. E., Kline, S. E., Selmecki, A. (2025). Heterogeneity of Candida bloodstream isolates in an academic medical center and affiliated hospitals. bioRxiv : the preprint server for biology. PMID: 39975022 PMCID: PMC11839140 doi: 10.1101/2025.02.05.636768
  4. Zhou, X., Hilk, A., Solis, N. V., Scott, N., Beach, A., Soisangwan, N., Billings, C. L., Burrack, L. S., Filler, S. G., Selmecki, A. (2024). Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans. Nature microbiology, 9(11), 2923-2938. PMID: 39227665 PMCID: PMC11524788 doi: 10.1038/s41564-024-01795-7
  5. Vande Zande, P., Gautier, C., Kawar, N., Maufrais, C., Metzner, K., Wash, E., Beach, A. K., Bracken, R., Maciel, E. I., de Pereira Sá, N., Fernandes, C. M., Solis, N. V., Del Poeta, M., Filler, S. G., Berman, J., Ene, I. V., Selmecki, A. (2024). Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans. PLoS pathogens, 20(8), e1012497. PMID: 39213436 PMCID: PMC11392398 doi: 10.1371/journal.ppat.1012497
  6. MacAlpine, J., Daniel-Ivad, M., Liu, Z., Yano, J., Revie, N. M., Todd, R. T., Stogios, P. J., Sanchez, H., O'Meara, T. R., Tompkins, T. A., Savchenko, A., Selmecki, A., Veri, A. O., Andes, D. R., Fidel, Jr, P. L., Robbins, N., Nodwell, J., Whitesell, L., Cowen, L. E. (2024). Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nature communications, 15(1), 6440. PMID: 39090082 PMCID: PMC11294323 doi: 10.1038/s41467-024-50740-z
  7. Zhou, X., Hilk, A., Solis, N. V., De Pereira Sa, N., Hogan, B. M., Bierbaum, T. A., Del Poeta, M., Filler, S. G., Burrack, L. S., Selmecki, A. (2024). Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes. PLoS pathogens, 20(7), e1012389. PMID: 39078851 PMCID: PMC11315318 doi: 10.1371/journal.ppat.1012389
  8. Zhou, X., Hilk, A., Solis, N. V., Hogan, B. M., Bierbaum, T. A., Filler, S. G., Burrack, L. S., Selmecki, A. (2024). Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes. bioRxiv : the preprint server for biology. PMID: 38496635 PMCID: PMC10942443 doi: 10.1101/2024.03.06.583770
  9. Kohanovski, I., Pontz, M., Vande Zande, P., Selmecki, A., Dahan, O., Pilpel, Y., Yona, A. H., Ram, Y. (2024). Aneuploidy Can Be an Evolutionary Diversion on the Path to Adaptation. Molecular biology and evolution, 41(3). PMID: 38427813 PMCID: PMC10951435 doi: 10.1093/molbev/msae052
  10. Selemcki, A. (Corresponding Author) (2023). Copy Number Variation and Allele Ratio Analysis in Candida albicans Using Whole Genome Sequencing Data. Methods in Molecular Biology(2658:105-125). PMID: 37024698  doi: 10.1007/978-1-0716-3155-3_8
  11. Selmecki, A. (Corresponding Author) (2023). The Dynamic Fungal Genome—Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress. Annual Reviews Microbiology. Annual Reviews Microbiology(77:X–X). doi.org/10.1146/annurev-micro-041320-112443
  12. Selmecki, A. (2023). Recurrent copy number variations in the human fungal pathogen Candida parapsilosis. mBio, 14(5), e0071323. PMID: 37787545 PMCID: PMC10653803 doi: 10.1128/mbio.00713-23
  13. Scott, N. E., Edwin Erayil, S., Kline, S. E., Selmecki, A. (2023). Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy. Antimicrobial agents and chemotherapy, 67(8), e0054323. PMID: 37428075 PMCID: PMC10433866 doi: 10.1128/aac.00543-23
  14. Todd, R. T., Soisangwan, N., Peters, S., Kemp, B., Crooks, T., Gerstein, A., Selmecki, A. (2023). Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans. Molecular biology and evolution, 40(1). PMID: 36649220 PMCID: PMC9887641 doi: 10.1093/molbev/msad009
  15. Selmecki, A. (Corresponding Author) (2023). Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans. Molecular Biology and Evolution. Molecular Biology and Evolution(40(1):msad009). PMCID: PMC9887641 doi: 10.1093/molbev/msad009. PMID: 36649220
  16. Todd, R. T., Selmecki, A. (2023). Copy Number Variation and Allele Ratio Analysis in Candida albicans Using Whole Genome Sequencing Data. Methods in molecular biology (Clifton, N.J.), 2658, 105-125. PMID: 37024698 PMCID: PMC10676714 doi: 10.1007/978-1-0716-3155-3_8
  17. Selmecki, A. (Corresponding Author) (2022). Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process. PLoS Genetics(18(12): e1010576). doi.org/10.1371/journal.pgen.1010576
  18. Rizzo, M., Soisangwan, N., Vega-Estevez, S., Price, R. J., Uyl, C., Iracane, E., Shaw, M., Soetaert, J., Selmecki, A., Buscaino, A. (2022). Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process. PLoS genetics, 18(12), e1010576. PMID: 36574460 PMCID: PMC9829183 doi: 10.1371/journal.pgen.1010576
  19. Selmecki, A. (Corresponding Author) (2022). Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo. mBio(;13(4):e0084222). PMID: 35862787 PMCID: PMC9426540 doi: 10.1128/mbio.00842-22
  20. MacAlpine, J., Daniel-Ivad, M., Liu, Z., Yano, J., Revie, N. M., Todd, R. T., Stogios, P. J., Sanchez, H., O'Meara, T. R., Tompkins, T. A., Savchenko, A., Selmecki, A., Veri, A. O., Andes, D. R., Fidel, Jr, P. L., Robbins, N., Nodwell, J., Whitesell, L., Cowen, L. E. (2021). A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nature communications, 12(1), 6151. PMID: 34686660 PMCID: PMC8536679 doi: 10.1038/s41467-021-26390-w
  21. Yang, F., Todd, R. T., Selmecki, A., Jiang, Y. Y., Cao, Y. B., Berman, J. (2021). The fitness costs and benefits of trisomy of each Candida albicans chromosome. Genetics, 218(2). PMID: 33837402 PMCID: PMC8225349 doi: 10.1093/genetics/iyab056
  22. Yang, F., Todd, R. T., Selmecki, A., Jiang, Y. Y., Cao, Y. B., Berman, J. (2021). The fitness costs and benefits of trisomy of each Candida albicans chromosome. Genetics. PMID: 33837402  doi: 10.1093/genetics/iyab056
  23. Todd, R. T., Selmecki, A. (2020). Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs. eLife, 9. PMID: 32687060 PMCID: PMC7371428 doi: 10.7554/eLife.58349
  24. Todd, R. T., Selmecki, A. (2020). Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs. eLife, 9. PMID: 32687060 PMCID: PMC7371428 doi: 10.7554/eLife.58349
  25. Harrison, L. B., Fowler, R. C., Abdalhamid, B., Selmecki, A., Hanson, N. D. (2019). lptG contributes to changes in membrane permeability and the emergence of multidrug hypersusceptibility in a cystic fibrosis isolate of Pseudomonas aeruginosa. MicrobiologyOpen, 8(11), e844. PMID: 30977288 PMCID: PMC6854846 doi: 10.1002/mbo3.844
  26. Harrison, L. B., Fowler, R. C., Abdalhamid, B., Selmecki, A., Hanson, N. D. (2019). lptG contributes to changes in membrane permeability and the emergence of multidrug hypersusceptibility in a cystic fibrosis isolate of Pseudomonas aeruginosa. MicrobiologyOpen, 8(11), e844. PMID: 30977288 PMCID: PMC6854846 doi: 10.1002/mbo3.844
  27. Todd, R. T., Wikoff, T. D., Forche, A., Selmecki, A. (2019). Genome plasticity in Candida albicans is driven by long repeat sequences. eLife, 8. PMID: 31172944 PMCID: PMC6591007 doi: 10.7554/eLife.45954
  28. Todd, R. T., Wikoff, T. D., Forche, A., Selmecki, A. (2019). Genome plasticity in Candida albicans is driven by long repeat sequences. eLife, 8. PMID: 31172944 PMCID: PMC6591007 doi: 10.7554/eLife.45954
  29. Forche, A., Solis, N. V., Swidergall, M., Thomas, R., Guyer, A., Beach, A., Cromie, G. A., Le, G. T., Lowell, E., Pavelka, N., Berman, J., Dudley, A. M., Selmecki, A., Filler, S. G. (2019). Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype. PLoS genetics, 15(5), e1008137. PMID: 31091232 PMCID: PMC6538192 doi: 10.1371/journal.pgen.1008137
  30. Forche, A., Solis, N. V., Swidergall, M., Thomas, R., Guyer, A., Beach, A., Cromie, G. A., Le, G. T., Lowell, E., Pavelka, N., Berman, J., Dudley, A. M., Selmecki, A., Filler, S. G. (2019). Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype. PLoS genetics, 15(5), e1008137. PMID: 31091232 PMCID: PMC6538192 doi: 10.1371/journal.pgen.1008137
  31. Harrison, L. B., Selmecki, A., Hanson, N. D. (2019). Draft Genome Assemblies of Clinical Isolates of Klebsiella pneumoniae V9011662 and Enterobacter hormaechei Entb306. Microbiology resource announcements, 8(15). PMID: 30975800 PMCID: PMC6460023 doi: 10.1128/MRA.00091-19
  32. Harrison, L. B., Selmecki, A., Hanson, N. D. (2019). Draft Genome Assemblies of Clinical Isolates of Klebsiella pneumoniae V9011662 and Enterobacter hormaechei Entb306. Microbiology resource announcements, 8(15). PMID: 30975800 PMCID: PMC6460023 doi: 10.1128/MRA.00091-19
  33. Polvi, E. J., Veri, A. O., Liu, Z., Hossain, S., Hyde, S., Kim, S. H., Tebbji, F., Sellam, A., Todd, R. T., Xie, J. L., Lin, Z. Y., Wong, C. J., Shapiro, R. S., Whiteway, M., Robbins, N., Gingras, A. C., Selmecki, A., Cowen, L. E. (2019). Functional divergence of a global regulatory complex governing fungal filamentation. PLoS genetics, 15(1), e1007901. PMID: 30615616 PMCID: PMC6336345 doi: 10.1371/journal.pgen.1007901
  34. Franke, J. D., Blomberg, W. R., Todd, R. T., Thomas, R. W., Selmecki, A. M. (2018). Assembly of a complete genome sequence for Gemmata obscuriglobus reveals a novel prokaryotic rRNA operon gene architecture. Antonie van Leeuwenhoek, 111(11), 2095-2105. PMID: 29785674  doi: 10.1007/s10482-018-1102-0
  35. Franke, J. D., Blomberg, W. R., Todd, R. T., Thomas, R. W., Selmecki, A. M. (2018). Assembly of a complete genome sequence for Gemmata obscuriglobus reveals a novel prokaryotic rRNA operon gene architecture. Antonie van Leeuwenhoek, 111(11), 2095-2105. PMID: 29785674  doi: 10.1007/s10482-018-1102-0
  36. Jelenić, I., Selmecki, A., Laan, L., Pavin, N. (2018). Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells. Frontiers in genetics, 9, 296. PMID: 30131823 PMCID: PMC6091489 doi: 10.3389/fgene.2018.00296
  37. Todd, R. T., Braverman, A. L., Selmecki, A. (2018). Flow Cytometry Analysis of Fungal Ploidy. Current protocols in microbiology, 50(1), e58. PMID: 30028911 PMCID: PMC6105418 doi: 10.1002/cpmc.58
  38. Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., Cowen, L. E. (2018). Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. PLoS genetics, 14(4), e1007319. PMID: 29702647 PMCID: PMC5922528 doi: 10.1371/journal.pgen.1007319
  39. Scott, A. L., Richmond, P. A., Dowell, R. D., Selmecki, A. M. (2017). The Influence of Polyploidy on the Evolution of Yeast Grown in a Sub-Optimal Carbon Source. Molecular biology and evolution, 34(10), 2690-2703. PMID: 28957510 PMCID: PMC5850772 doi: 10.1093/molbev/msx205
  40. Xie, J. L., Qin, L., Miao, Z., Grys, B. T., Diaz, J. C., Ting, K., Krieger, J. R., Tong, J., Tan, K., Leach, M. D., Ketela, T., Moran, M. F., Krysan, D. J., Boone, C., Andrews, B. J., Selmecki, A., Ho Wong, K., Robbins, N., Cowen, L. E. (2017). The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation. Nature communications, 8(1), 499. PMID: 28894103 PMCID: PMC5593949 doi: 10.1038/s41467-017-00547-y
  41. Selmecki, A. M., Maruvka, Y. E., Richmond, P. A., Guillet, M., Shoresh, N., Sorenson, A. L., De, S., Kishony, R., Michor, F., Dowell, R., Pellman, D. (2015). Polyploidy can drive rapid adaptation in yeast. Nature, 519(7543), 349-52. PMID: 25731168 PMCID: PMC4497379 doi: 10.1038/nature14187
  42. Selmecki, A. M. (Corresponding Author), Maruvka, Y. E., Richmond, P. A., Guillet, M., Shoresh, N., Sorenson, A. L., De, S., Kishony, R., Michor, F., Dowell, R., Pellman, D. (Corresponding Author) (2015). Polyploidy can drive rapid adaptation in yeast. Nature, 519(7543), 349-52. PMID: 25731168 PMCID: PMC4497379 doi: 10.1038/nature14187

Book Chapter

  1. Selmecki, A. M. (Corresponding Author), Maruvka, Y. E., Richmond, P. A., Guillet, M., Shoresh, N., Sorenson, A. L., De, S., Kishony, R., Michor, F., Dowell, R., Pellman, D. (Corresponding Author) (2015). Polyploidy can drive rapid adaptation in yeast. Nature, 519(7543), 349-52. PMID: 25731168 PMCID: PMC4497379 doi: 10.1038/nature14187

Editorial

  1. Perfect, J. R., Krysan, D. J., Del Poeta, M., Selmecki, A. M., Brown JCS, Cowen, L. E. (2022). Editorial: Antifungal Pipeline: Build It Strong; Build It Better! (vol. 12, pp. 881272). Frontiers in cellular and infection microbiology. PMID: 35372097 PMCID: PMC8965832 doi: 10.3389/fcimb.2022.881272
  2. Perfect, J. R., Krysan, D. J., Del Poeta, M., Selmecki, A. M., Brown JCS, Cowen, L. E. (2022). Editorial: Antifungal Pipeline: Build It Strong; Build It Better! (vol. 12, pp. 881272). Frontiers in cellular and infection microbiology. PMID: 35372097 PMCID: PMC8965832 doi: 10.3389/fcimb.2022.881272
  3. Perfect, J. R., Krysan, D. J., Del Poeta, M., Selmecki, A. M., Brown JCS, Cowen, L. E. (2022). Editorial: Antifungal Pipeline: Build It Strong; Build It Better! (vol. 12, pp. 881272). Frontiers in cellular and infection microbiology. PMID: 35372097 PMCID: PMC8965832 doi: 10.3389/fcimb.2022.881272